Prenatal THC Does Not Affect Female Mesolimbic Dopaminergic System in Preadolescent Rats
Abstract Cannabis use among pregnant women is increasing worldwide along with permissive sociocultural attitudes toward it. Prenatal cannabis exposure (PCE),…
electrophysiology
Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models
Abstract Patients with a serious mental illness often use cannabis at higher rates than the general population and are also…
Cannabidiol interactions with voltage-gated sodium channels
Abstract Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol…
The electrophysiological effect of cannabidiol on hERG current and in guinea-pig and rabbit cardiac preparations
Abstract Cannabis use is associated with cardiovascular adverse effects ranging from arrhythmias to sudden cardiac death. The exact mechanism of…
Δ9-Tetrahydrocannabinol During Adolescence Attenuates Disruption of Dopamine Function Induced in Rats by Maternal Immune Activation
Abstract The combination of prenatal, such as maternal infections, and postnatal environmental insults (e.g., adolescent drug abuse) increases risks for…
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
Abstract Background: Considering the poorly understood etiology and complex symptoms of chronic neuropathic pain (NP), the lack of effective treatments,…
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain
Abstract Low dose of cannabidiol ameliorates mechanical allodynia and anxious behavior and restores impaired serotonergic transmission in a neuropathic pain…
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Abstract Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and…
Adolescent Synthetic Cannabinoid Exposure Produces Enduring Changes in Dopamine Neuron Activity in a Rodent Model of Schizophrenia Susceptibility
Abstract Background: Epidemiological studies recognize cannabis intake as a risk factor for schizophrenia, yet the majority of adolescents who use…
Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research
Abstract Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition…