CDKL5 deficiency-related neurodevelopmental disorders: a multi-center cohort study in Italy
Abstract CDKL5 deficiency disorder (CDD) is a complex clinical condition resulting from non-functional or absent CDKL5 protein, a serine–threonine kinase…
EEG
A case of clinical worsening after stereo-electroencephalographic-guided radiofrequency thermocoagulation in a patient with polymicrogyria
Abstract A 35-year-old man reported seizures worsening and postictal psychosis after Radiofrequency-Thermocoagulation (RF-TC). Cannabidiol treatment improved seizure frequency/intensity, resolving the…
The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
Abstract Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist…
Use of a Novel EEG-Based Objective Test, the Cognalyzer®, in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework
Abstract Introduction: Current methods to detect recent delta-9-tetrahydrocannabinol (THC) use cannot objectively quantify its psychoactive effects (PE). The Cognalyzer®, an…
Theta and Alpha Oscillatory Activity During Working Memory Maintenance in Long-Term Cannabis Users: The Importance of the Polydrug Use Context
Abstract Background: Impairments in various subdomains of memory have been associated with chronic cannabis use, but less is known about…
Not Just a Pot: Visual Episodic Memory in Cannabis Users and Polydrug Cannabis Users: ROC and ERP Preliminary Investigation
Abstract Background While research has consistently identified an association between long-term cannabis use and memory impairments, few studies have examined…
Sensitivity, Specificity and Accuracy of a Novel EEG-Based Objective Test, the Cognalyzer®, in Detecting Cannabis Psychoactive Effects
Abstract Introduction: Current standards for identifying recent cannabis use are based on body fluid testing. The Cognalyzer® is a novel…
Global brain network dynamics predict therapeutic responsiveness to cannabidiol treatment for refractory epilepsy
Abstract Refractory epilepsy is a chronic brain network disorder characterized by unresponsiveness to multiple (>2) anti-epileptic drugs. Cannabidiol, a non-psychotropic…
Effect of Cannabinoids on Electroencephalography of a Child with Lennox–Gastaut Syndrome
Abstract Cannabinoids have been found to be effective in controlling seizures and the highly purified form of cannabinoid derived for…
Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol
Abstract We observed that cannabidiol supplements were highly effective in treating an infant boy with drug-resistant early infantile epileptic encephalopathy,…