Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis
Abstract Simple Summary: Somatic mutations are one of the most important causal factors of cancers. In this study, we show…
Drug sensitivity
Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
Abstract Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing…
Pan‐cancer analysis reveals the oncogenic role of 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1
Abstract Background: Emerging studies reveals that 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1 (HMGCS1) plays vital oncogenic roles in a broad spectrum of human…
Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors
Keywords: DOK, Tumor microenvironment, Immune infiltration, Drug sensitivity Authors: Yongjun Guan, Man Li, Zhendong Qiu, Junhui Xu, Yichao Zhang, Ning…
Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of N6-Methyladenosine RNA Modification Regulators in Human Cancers
Abstract N6-methyladenosine RNA modification plays a significant role in the progression of multiple tumorigenesis. Our study identified the imperative role…
A pan-cancer study of selenoprotein genes as promising targets for cancer therapy
Abstract Background: The most important health benefit of selenium (Se) is in the prevention and control of cancer. Glutathione peroxidases…
A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer
Abstract Background: Initially characterized as axon guidance factors, semaphorins also have been implicated to have critical roles in multiple physiological…
Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer
Abstract Background: Inhibitors of apoptosis proteins (IAPs) are a family of antiapoptotic proteins modulating cell cycle, signal transduction and apoptosis.…