drug discrimination

September 18, 2025

Tetrahydrocannabivarin (THCV) Dose Dependently Blocks or Substitutes for Tetrahydrocannabinol (THC) in a Drug Discrimination Task in Rats

Abstract Delta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1…

April 17, 2025

Discriminating evidence – use and misuse of the drug-discrimination test in abuse potential assessment of novel CNS drugs

Abstract Nonclinical testing to predict the abuse potential of central nervous system (CNS) drug candidates is a mandatory part of…

November 10, 2023

Δ9-tetrahydrocannabinol discrimination: Effects of route of administration in mice

Abstract We examined if route of administration altered THC’s discriminative stimulus in mice. i.p., p.o., s.c., and aerosolized THC fully…