From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design
Abstract Pain is associated with many health problems and a reduced quality of life and has been a common reason…
Drug discovery
Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold
Abstract TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and…
Rational optimization of a transcription factor activation domain inhibitor
Abstract Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable’ in part due to the…
Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives
Abstract (−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to…
Characterization and in-vitro Alzheimer’s properties of exopolysaccharide from Bacillus maritimus MSM1
Abstract Four bacterial isolates were obtained from marine sediments collected from Sahl Hashish, Hurghada Red Sea, Egypt. This study was…
The pharmacology and therapeutic role of cannabidiol in diabetes
Abstract In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad…
CBGA ameliorates inflammation and fibrosis in nephropathy
Abstract Cannabidiol (CBD) is thought to have multiple biological effects, including the ability to attenuate inflammatory processes. Cannabigerols (CBGA and…
Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy
Abstract Simple Summary: Cancer is a leading cause of death worldwide and continuous efforts are exerted to develop novel biomarkers…
Molecular Modeling Targeting the ACE2 Receptor with Cannabis sativa’s Active Ingredients for Antiviral Drug Discovery against SARS-CoV-2 Infections
Abstract The emergence of a novel coronavirus that later on rendered a global pandemic, caused desperation within the communities and…
Drug reprofiling history and potential therapies against Parkinson’s disease
Abstract Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old”…