Prefrontal cortex and putamen grey matter alterations in cannabis and tobacco users
Abstract Background: Previous magnetic resonance imaging studies in regular cannabis users report altered grey matter volume (GMV) in brain regions,…
Dorsolateral prefrontal cortex
Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network
Abstract Cannabidiol (CBD) is a phytocannabinoid contained in the Cannabis sativa plant, devoid of psychotomimetic effects but with a broad-spectrum…
Intravenous self-administration of delta-9-THC in adolescent rats produces long-lasting alterations in behavior and receptor protein expression
Abstract Rationale: Initial exposure to cannabinoids, including Δ-9-tetrahydrocannabinol (THC), often occurs during adolescence. Considerable neurodevelopmental alterations occur throughout adolescence, and…
Maternal Exposure to the Cannabinoid Agonist WIN 55,12,2 during Lactation Induces Lasting Behavioral and Synaptic Alterations in the Rat Adult Offspring of Both Sexes
Abstract Consumption of cannabis during pregnancy and the lactation period is a rising public health concern (ref. Scheyer et al.,…
Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood
Abstract Heavy cannabis consumption among adolescents is associated with significant and lasting neurobiological, psychological and health consequences that depend on…
The neuropsychopharmacology of cannabis: A review of human imaging studies
Abstract The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in…
Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries
Abstract Alcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when…
Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder
Abstract Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this…
Using Functional Near-Infrared Spectroscopy to Measure Effects of Delta 9-Tetrahydrocannabinol on Prefrontal Activity and Working Memory in Cannabis Users
Abstract Intoxication from cannabis impairs cognitive performance, in part due to the effects of Δ9-tetrahydrocannabinol (THC, the primary psychoactive compound…
Δ9-Tetrahydrocannabinol Experience Influences ΔFosB and Downstream Gene Expression in Prefrontal Cortex
Abstract Introduction: Repeated administration of abused drugs, including Δ9-tetrahydrocannabinol (THC), induces the stable transcription factor ΔFosB in dopaminergic terminal field…