Cannabis use and the sperm epigenome: a budding concern?
Abstract The United States is swiftly moving toward increased legalization of medical and recreational cannabis. Currently considered the most commonly…
DNA methylation
The Epigenetics of the Endocannabinoid System
Abstract The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and…
The role of HOPX in normal tissues and tumor progression
Abstract The homeodomain-only protein homeobox (HOPX) as the smallest homeodomain protein, lacks certain conserved residues required for DNA binding. Through…
Integrative Analysis of Methylation and Transcriptome Identified Epigenetically Regulated lncRNAs With Prognostic Relevance for Thyroid Cancer
Abstract Emerging evidence has shown that epigenetic changes in DNA methylation, an important regulator of long non-coding RNA (lncRNA) expression,…
Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors
Abstract Background: Dysregulation of alternative splicing (AS) is a critical signature of cancer. However, the regulatory mechanisms of cancer-specific AS…
Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm
Abstract Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is…
Absence of an embryonic stem cell DNA methylation signature in human cancer
Abstract Background: Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory…
Impacts of cannabinoid epigenetics on human development: reflections on Murphy et. al. ‘cannabinoid exposure and altered DNA methylation in rat and human sperm’ epigenetics 2018; 13: 1208-1221.
Abstract Recent data from the Kollins lab (‘Cannabinoid exposure and altered DNA methylation in rat and human sperm’ Epigenetics 2018;…
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Abstract Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this…
Cannabinoid exposure and altered DNA methylation in rat and human sperm
Abstract Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC)…