Interaction of cytochrome P450 3A4 with cannabinoids and the drug darifenacin
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug-metabolizing enzyme whose substrate binding mechanism remains incompletely understood because of insufficient…
crystal structure
Cannabidiol interactions with voltage-gated sodium channels
Abstract Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol…
R‐hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis—A new entry to the carrier protein family Lipocalines
Abstract We determined the X‐ray crystallographic structure of a unique hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis, and elucidated…
Characterization of Two VAO-Type Flavoprotein Oxidases from Myceliophthora thermophila
Abstract The VAO flavoprotein family consists mostly of oxidoreductases harboring a covalently linked flavin cofactor. The linkage can be either…
High-resolution crystal structure of the human CB1 cannabinoid receptor
Abstract The human cannabinoid G protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and…