Valorization of Thyme Combined with Phytocannabinoids as Anti-Inflammatory Agents for Skin Diseases
Abstract Background: Skin diseases of inflammatory origin, such as atopic dermatitis, psoriasis and acne, have a substantial prevalence in the…
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Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Abstract MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological…
Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product‐Based Therapies
Abstract Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients’ quality of life, imposes significant psychological…
Influence of Plant-Based Substrate Composition and Extraction Method on Accumulation of Bioactive Compounds in Hericium erinaceus (Bull.) Pers. Fruiting Bodies
Abstract The selection of plant-based substrates for mushroom cultivation is a key factor influencing their growth and metabolism. The aim…
Characterization of the Volatile Compounds of the Hardwood Portion of Betula papyrifera Marshall From Quebec, Canada
Abstract Betula papyrifera Marshall (paper birch) hardwood is an abundant yet underutilized resource for Quebec’s forestry industry. We investigated the…
Complex forming properties of cannabinoid acids in a green solvent and bioassays focused on gastric disease caused by Helicobacter pylori infection
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-03442-5. Article type: Research Article Keywords: Cannabinoid acids, Copper(II)…
Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection
Abstract Phytocannabinoids are attracting growing attention because of their potential for treatment of neurodegenerative diseases. Among them, the “minor” cannabinoid,…
Microbial biosynthesis of rare cannabinoids
Abstract ∆9–tetrahydrocannabinol (∆9–THC) and cannabidiol are the most abundant natural cannabinoids isolated from the different cultivars of the Cannabis plant.…
The Potential of Nano-Formulated Natural Drugs in Melanoma Treatment: A Review of Pharmacological Efficacy and Mechanistic Insights
Abstract Melanoma is a very aggressive skin cancer; its treatment bears great challenges, hence the interest in new therapeutic approaches…
Systematic biotechnological production of isoprenoid analogs with bespoke carbon skeletons
Abstract Natural products are widely used as pharmaceuticals, flavors, fragrances, and cosmetic ingredients. Synthesizing and evaluating analogs of natural products…