Diagnostic classification of cancers using DNA methylation of paracancerous tissues
Abstract The potential role of DNA methylation from paracancerous tissues in cancer diagnosis has not been explored until now. In…
Computational biology and bioinformatics
An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors
Abstract In recent years, several studies have suggested that mitochondrial creatine kinase 1A (CKMT1A) plays a key role in various…
Role of CD47 in tumor immunity: a potential target for combination therapy
Abstract CD47 performs a vital function in cancer therapy by binding to different SIRPα, thrombospondin 1, and integrin. However, its…
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors
Abstract Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1) is believed to function as a tumor suppressor, while Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2)…
Computing microRNA-gene interaction networks in pan-cancer using miRDriver
Abstract DNA copy number aberrated regions in cancer are known to harbor cancer driver genes and the short non-coding RNA…
Systematic evaluation of the prognostic and immunological role of PDLIM2 across 33 cancer types
Abstract The protein PDLIM2 regulates the stability of various transcription factors and is required for polarized cell migration. However, the…
Understanding the role of the CB1 toggle switch in interaction networks using molecular dynamics simulation
Abstract The cannabinoid receptor 1 (CB1) is a class A G-protein coupled receptor (GPCR) that can exert various effects on…
Convolutional neural network for human cancer types prediction by integrating protein interaction networks and omics data
Abstract Many studies have proven the power of gene expression profile in cancer identification, however, the explosive growth of genomics…
Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
Abstract Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase…
Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
Abstract Thyroid Carcinoma (THCA) is the most common endocrine tumor that is mainly treated using surgery and radiotherapy. In addition,…