Long-term cancer survival prediction using multimodal deep learning
Abstract The age of precision medicine demands powerful computational techniques to handle high-dimensional patient data. We present MultiSurv, a multimodal…
Computational biology and bioinformatics
Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
Abstract Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is…
The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Abstract Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly…
Systematic investigation of promoter substitutions resulting from somatic intrachromosomal structural alterations in diverse human cancers
Abstract One of the ways in which genes can become activated in tumors is by somatic structural genomic rearrangements leading…
An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles
Abstract Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune evasion. Previous studies evaluated ITH mostly based…
CODC: a Copula-based model to identify differential coexpression
Abstract Differential coexpression has recently emerged as a new way to establish a fundamental difference in expression pattern among a…
Generation of a Comprehensive Transcriptome Atlas and Transcriptome Dynamics in Medicinal Cannabis
Abstract Cannabinoids are the main medicinal compounds of interest in the plant Cannabis sativa, that are primarily synthesised in the…