MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer
Abstract Microchromosome maintenance (MCM) proteins are a number of nuclear proteins with significant roles in the development of cancer by…
comparative oncology
Bioinformatic analysis of m6A “reader” YTH family in pan-cancer as a clinical prognosis biomarker
Abstract The m6A methylation of mRNA has been demonstrated to interact with the “Reader”. YTH domain family is one of…
An efficient context-aware approach for whole-slide image classification
Abstract Computational pathology for gigapixel whole-slide images (WSIs) at slide level is helpful in disease diagnosis and remains challenging. We…
Comprehensive analysis of TLX2 in pan cancer as a prognostic and immunologic biomarker and validation in ovarian cancer
Abstract T cell leukemia homeobox 2 (TLX2) plays an important role in some tumors. Bioinformatics and experimental validation represent a…
Comprehensive analysis of PILRΑ’s association with the prognosis, tumor immune infiltration, and immunotherapy in pan-cancer
Abstract Paired immunoglobulin-like type 2 receptor alpha (PILRA) plays a vital role in regulating broad immune responses. However, the roles…
Data mining on identifying diagnosis and prognosis biomarkers in head and neck squamous carcinoma
Abstract Head and neck squamous carcinoma (HNSC) induces high cancer-related death worldwide. The biomarker screening on diagnosis and prognosis is…
Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis
Abstract Previous research has demonstrated that ferredoxin 1 (FDX1) contributes to the accumulation of toxic lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and…
High expression of RNF31 is associated with tumor immune cell infiltration and leads to poor prognosis in liver hepatocellular carcinoma
Abstract Ring finger protein 31 (RNF31) has been found to play an important role in tumor immunity. However, the role…
Pan-cancer analysis reveals IGFL2 as a potential target for cancer prognosis and immunotherapy
Abstract Insulin-like growth factor like family member 2 (IGFL2) is a gene in the IGFL family, located on chromosome 19,…
Validation of transcriptome signature reversion for drug repurposing in oncology
Abstract Transcriptome signature reversion (TSR) has been extensively proposed and used to discover new indications for existing drugs (i.e. drug…