Analysis of the regulatory mechanisms of prognostic immune factors in thyroid cancer
Abstract Objective: To explore the regulatory mechanism of immune prognostic factors in thyroid cancer. Methods: Based on the TCGA database…
circulating miRNAs
Comprehensive Analysis of FASN in Tumor Immune Infiltration and Prognostic Value for Immunotherapy and Promoter DNA Methylation
Abstract Fatty acid synthase (FASN) promotes tumor progression in multiple cancers. In this study, we comprehensively examined the expression, prognostic…
Pan-cancer analysis of LncRNA XIST and its potential mechanisms in human cancers
Abstract Background: X-inactive specific transcript (XIST), it has been found, is abnormal expression in various neoplasms. This work aims to…
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma
Abstract Background: Pancreatic adenocarcinoma (PAAD) is a treatment-refractory cancer with poor prognosis. Accumulating evidence suggests that squalene epoxidase (SQLE) plays…
Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects
Abstract Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection…
MiRNA Deregulation Distinguishes Anaplastic Thyroid Carcinoma (ATC) and Supports Upregulation of Oncogene Expression
Abstract Simple Summary: MicroRNAs are essential regulators of gene expression. Their deregulation is associated with a substantial reorganization of the…
Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors
Abstract Context: Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk is currently predicted using clinical…
Novel Insights into Epigenetic Regulation of IL6 Pathway: In Silico Perspective on Inflammation and Cancer Relationship
Abstract IL-6 pathway is abnormally hyperactivated in several cancers triggering tumor cell growth and immune system inhibition. Along with genomic…
MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways
Abstract The aberrant expression of miRNAs is often correlated to tumor development. MiR-7-5p is a recently discovered downregulated miRNA in…
The Significance of Secreted Phosphoprotein 1 in Multiple Human Cancers
Abstract Malignant tumor represents a major reason for death in the world and its incidence is growing rapidly. Developing the…