Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability
Abstract Telomerase activity plays an essential role in tumor growth and varies across cancers, typically classified as low or high…
cellular senescence
Cannabinoid Derived Product is a Potential Novel Therapeutic for Papillary Thyroid Carcinoma
Abstract Rationale: Papillary thyroid carcinoma (PTC) is the most common thyroid cancer that typically affects women ages 20 to 50,…
Exploring the genetic profiles linked to senescence in thyroid tumors: insights on predicting disease progression and immune responses
Abstract Introduction: Thyroid cancer (THCA) is the most common endocrine tumor. Research on Cell Senescence Associated Genes (CSAGs), which impact…
Inhibition of Myeloma Cell Function by Cannabinoid-Enriched Product Associated With Regulation of Telomere and TP53
Abstract Multiple myeloma is a hematological cancer caused by the uncontrolled proliferation of abnormal plasma cells in the bone marrow,…
The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-024-01107-9. Article type: Research Article Keywords: LOXL2, Pan-cancer analysis,…
Cannabidiol suppresses proliferation and induces cell death, autophagy and senescence in human cholangiocarcinoma cells via the PI3K/AKT/mTOR pathway
Abstract Background and aim: Cholangiocarcinoma (CCA) is usually diagnosed at a late stage, leading to treatment failure. Cannabidiol (CBD), exhibits…
Comprehensive analysis of cellular senescence and immune microenvironment in papillary thyroid carcinoma
Abstract Senescence-induced therapy was previously considered as an effective treatment for tumors, and cellular senescence was initially regarded as an…
Bioinformatics analysis of the prognostic and clinical value of senescence-related gene signature in papillary thyroid cancer
Abstract Cellular senescence can both inhibit and promote the occurrence of tumors, so how to apply cellular senescence therapy is…
Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy
Abstract Introduction: Cellular senescence is a hallmark of tumors and has potential for cancer therapy. Cellular senescence of tumor cells…
The Novel Tumor Suppressor Gene ZNF24 Induces THCA Cells Senescence by Regulating Wnt Signaling Pathway, Resulting in Inhibition of THCA Tumorigenesis and Invasion
Abstract Object: Clinically, the effective treatment options available to thyroid cancer (THCA) patients are very limited. Elucidating the features of…