Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study
Abstract The endocannabinoid system (ECS) plays a critical role in fear learning and maintenance and may, therefore, be implicated in…
Cellular neuroscience
Abnormalities of the endocannabinoid system produce piercing nuclear hernias in migrating cerebral neurons
Abstract We are reporting powerful streams of chromatin rupturing the nuclear envelope (NE) and the plasma membrane of migrating cerebral…
Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories
Abstract As high-potency cannabis (with high Δ9-Tetrahydrocannabinol content) becomes easily accessible and widespread, it is of extreme importance for public…
Metabolomic profiling of cannabis use and cannabis intoxication in humans
Abstract Acute intoxication from Δ9-tetrahydrocannabinol (THC, the primary active ingredient of cannabis) can lead to neurocognitive impairment and interference with…
Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models
Abstract Most of the fear literature on humans and animals tests healthy individuals. However, fear memories can differ between healthy…
Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus
Abstract Hippocampal ripples project reactivated memories to many brain areas, and recently it has been proposed that different types of…
Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial
Abstract Although alcohol use disorder (AUD) is highly prevalent, only a few medications are approved for its treatment leaving much…
The endocannabinoid system in the brain undergoes long-lasting changes following neuropathic pain
Abstract The endocannabinoid system (ECS), which is composed of endocannabinoids (eCBs), cannabinoid receptors (CBRs), and associated signaling molecules, has been…
Impact of cannabinoids on synapse markers in an SH-SY5Y cell culture model
Abstract Patients suffering from schizophrenic psychosis show reduced synaptic connectivity compared to healthy individuals, and often, the use of cannabis…
LY-2183240 enhances reward-seeking behavior with inducing neuronal excitation and early apoptosis in mouse
Abstract Cannabinoids interact with cannabinoid receptors, influencing diverse central nervous system (CNS) and peripheral functions, including anxiety, depression, and cognition.…