A Regulatory Take on Cannabis and Cannabinoids for Medicinal use in the European Union
Abstract The discovery of the endocannabinoid system has raised public interest in the medicinal use of cannabis, phytocannabinoids, and synthetic…
cannabis-derived phytocannabinoids
Toxicological Properties of Δ9-tetrahydrocannabinol and Cannabidiol
Abstract Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of…
Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study
Abstract Phytocannabinoids (pCBs) are a large family of meroterpenoids isolated from the plant Cannabis sativa. Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD)…
Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin
Abstract Phytocannabinoids protect neurons against stressful conditions, possibly via the heme oxygenase (HO) system. In cultures of primary mesencephalic neurons…
Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens
Abstract Cannabis use is an emergent risk factor for periodontitis, a chronic bacterial-induced disease of the supporting structures of the…
Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses
Abstract Introduction: Phytocannabinoids, characteristic compounds produced by medical cannabis, interact with cannabinoid (CB) receptors (CB1 and CB2) as well as…
Terpenoids and Phytocannabinoids Co-Produced in Cannabis Sativa Strains Show Specific Interaction for Cell Cytotoxic Activity
Abstract Mixtures of different Cannabis sativa phytocannabinoids are more active biologically than single phytocannabinoids. However, cannabis terpenoids as potential instigators…
A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age
Abstract Objectives: There is a rapidly evolving legal and medical culture around cannabis, with corresponding changes in the demographics of…
Regulatory Status of Cannabidiol in the United States: A Perspective
Abstract Cannabidiol (CBD) is 1 of > 100 cannabinoids found in Cannabis sativa L. (Cannabis spp. or Cannabis). Despite its…
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Abstract Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and…