Neuroprotection by (Endo)Cannabinoids in Glaucoma and Retinal Neurodegenerative Diseases
Abstract Background: Emerging neuroprotective strategies are being explored to preserve the retina from degeneration, that occurs in eye pathologies like…
cannabis-derived phytocannabinoids
In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid
Abstract Inflammation and oxidative stress play main roles in neurodegeneration. Interestingly, different natural compounds may be able to exert neuroprotective…
Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes
Abstract Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L. that is attracting pharmacological interest because…
Review of the neurological benefits of phytocannabinoids
Abstract Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600…
Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors
Abstract The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa L., is not completely understood.…
Explorative Placebo-Controlled Double-Blind Intervention Study with Low Doses of Inhaled Δ9-Tetrahydrocannabinol and Cannabidiol Reveals No Effect on Sweet Taste Intensity Perception and Liking in Humans
Abstract Introduction: The endocannabinoid system (ECS) plays an important role in food reward. For example, in humans, liking of palatable…
Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two
Abstract Introduction:Cannabis biosynthesizes Δ9-tetrahydrocannabinolic acid (THCA-A), which decarboxylates into Δ9-tetrahydrocannabinol (THC). There is growing interest in the therapeutic use of…
Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats
Abstract Rationale: The appetite-stimulating properties of cannabis are well documented and have been predominantly attributed to the hyperphagic activity of…
The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation
Abstract The cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from Cannabis sativa highlighted by…
Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function
Abstract Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in…