Syntheses of Cannabinoid Metabolites: Ajulemic Acid and HU-210
Abstract Cannabinoid metabolites have been reported to be more potent than their parent compounds. Among them, ajulemic acid (AJA) is…
cannabis-derived phytocannabinoids
Cannabinerol (CBNR) Influences Synaptic Genes Associated with Cytoskeleton and Ion Channels in NSC-34 Cell Line: A Transcriptomic Study
Abstract Cannabinoids are receiving great attention as a novel approach in the treatment of cognitive and motor disabilities, which characterize…
Evaluating Sex Differences in Efficacy, Safety and Pharmacokinetics in Patients Treated with Cannabis by a Metered-Dose Inhaler
Abstract Background: Clinical studies on medical cannabis (MC) treatment have shown sex-related differences, including higher susceptibility to adverse events among…
Phytocannabinoids Reduce Seizures in Larval Zebrafish and Affect Endocannabinoid Gene Expression
Abstract Cannabis has demonstrated anticonvulsant properties, and about thirty percent of epileptic patients do not have satisfactory seizure management with…
A type II cannabis extract and a 1:1 blend of Δ(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space
Abstract Introduction: Cannabis extracts are being increasingly used to mitigate chronic pain. Current guidelines for their prescription rely on Δ9-tetrahydrocannabinol…
Enhanced production of select phytocannabinoids in medical Cannabis cultivars using microbial consortia
Abstract The root microbiome of medical cannabis plants has been largely unexplored due to past legal restrictions in many countries.…
The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation
Abstract Introduction: Extracts and compounds isolated from hemp (Cannabis sativa) are increasingly gaining popularity in the treatment of a number…
Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA
Abstract The action of UVA radiation (both that derived from solar radiation and that used in the treatment of skin…
Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing
Abstract Although medical cannabis was legalized in Czechia in 2013 and its use in topical treatments of skin disorders is…
Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
Abstract Phytocannabinoids, including the non-addictive cannabis component cannabidivarin (CBDV), have been reported to hold therapeutic potential in several neurodevelopmental disorders…