A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay
Abstract Introduction: The kinetics of ligand binding to G protein-coupled receptors (GPCRs) is an important optimization parameter in drug discovery.…
cannabinoid type 1 receptor
Systematic review/meta‐analysis on the role of CB1R regulation in sleep‐wake cycle in rats
Abstract Objective: A systematic review/meta‐analysis was conducted to investigate the effect of cannabinoid type‐1 receptor (CB1R) regulation on the sleep‐wake…
Structure–Activity Relationship and Functional Evaluation of Cannabinoid Type-1 Receptor
Abstract The type-1 cannabinoid receptor (CB1R) is a potential therapeutic target in several pathological conditions, including neuropsychological disorders and neurodegenerative…
Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical model
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00210-023-02923-6. Article type: Research Article Keywords: Cannabinoid type 1…
Role of CB1 Cannabinoid Receptors in Vascular Responses and Vascular Remodeling of the Aorta in Female Mice
Abstract Both the endocannabinoid system (ECS) and estrogens have significant roles in cardiovascular control processes. Cannabinoid type 1 receptors (CB1Rs)…
Sex and stressor modality influence acute stress-induced dynamic changes in corticolimbic endocannabinoid levels in adult Sprague Dawley rats
Abstract Research over the past few decades has established a role for the endocannabinoid system in contributing to the neural…
ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β-Smad2/3 Signaling-Mediated Lung Fibroblast Activation
Abstract Pulmonary fibrosis is a group of life-threatening diseases with limited therapeutic options. The involvement of cannabinoid type 1 receptors…
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
Protein Interactors and Trafficking Pathways That Regulate the Cannabinoid Type 1 Receptor (CB1R)
Abstract The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress synaptic transmission and plays a major role…
Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
Abstract The endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its…