Biosynthesis of Nature-Inspired Unnatural Cannabinoids
Abstract Natural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one…
Cannabinoid receptors
Molecular Mechanism of Autophagy and Its Regulation by Cannabinoids in Cancer
Abstract Simple Summary: This review examines the complex function of autophagy in malignancy and explores its regulation by cannabinoids in…
The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation
Abstract Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors…
The Immunopathology of COVID-19 and the Cannabis Paradigm
Abstract Coronavirus disease-19 caused by the novel RNA betacoronavirus SARS-CoV2 has first emerged in Wuhan, China in December 2019, and…
Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses
Abstract For thousands of years, Cannabis sativa has been utilized as a medicine and for recreational and spiritual purposes. Phytocannabinoids…
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Abstract Recently, there has been a growing interest in the medical applications of Cannabis plants. They owe their unique properties…
New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling
Abstract Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2…
The Immune Endocannabinoid System of the Tumor Microenvironment
Abstract Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory…
Does cannabis alleviate tinnitus? A review of the current literature
Abstract Objective(s): Endocannabinoid pathways have been proposed to affect the underlying pathophysiology of tinnitus. The aim of this study is…
Advances in Neurobiology and Pharmacology of GPR12
Abstract GPR12 is a G protein-coupled orphan receptor genetically related to type 1 and type 2 cannabinoid receptors (CB1 and…