Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
Abstract Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop,…
Cannabidiol derivative/ NRF2/ BACH1/ HMOX1/ neurodegenerative diseases
Differences in Striatal Metabolism in [18F]FDG PET in Parkinson’s Disease and Atypical Parkinsonism
Abstract Neurodegenerative parkinsonisms affect mainly cognitive and motor functions and are syndromes of overlapping symptoms and clinical manifestations such as…
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Abstract Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers…
Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential
Abstract Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of…
The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress
Abstract Cannabidiol (CBD), the major non-psychoactive phytocannabinoid of Cannabis sativa L., is one of the most studied compounds in pharmacotherapeutic…
Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents
Abstract Nowadays, neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis…
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2
Abstract Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and…
Parkinson’s Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment
Abstract Accumulating data suggest that chronic neuroinflammation-mediated neurodegeneration is a significant contributing factor for progressive neuronal and glial cell death…
The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins
Abstract Molecular chaperones safeguard cellular protein homeostasis and obviate proteotoxicity. In the process of aging, as chaperone networks decline, aberrant…
Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
Abstract The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved…