Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Abstract Most neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a critical…
Cannabidiol derivative/ NRF2/ BACH1/ HMOX1/ neurodegenerative diseases
Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases
Abstract Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective…
Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer’s Disease
Abstract The endocannabinoid system has been linked to various physiological and pathological processes, because it plays a neuromodulator role in…
The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells
Abstract The global increase in the aging population has led to a rise in many age-related diseases with continuing unmet…
Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
Abstract Alzheimer’s disease (AD), the most common neurodegenerative disease (NDD), is characterized by chronic neuronal cell death through progressive loss…
Cannabinoids in Medicine: A Multifaceted Exploration of Types, Therapeutic Applications, and Emerging Opportunities in Neurodegenerative Diseases and Cancer Therapy
Abstract In this review article, we embark on a thorough exploration of cannabinoids, compounds that have garnered considerable attention for…
Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice
Abstract Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system.…
Redox Imbalance in Neurological Disorders in Adults and Children
Abstract Oxygen is a central molecule for numerous metabolic and cytophysiological processes, and, indeed, its imbalance can lead to numerous…
Impact of the Cannabinoid System in Alzheimer’s Disease
Abstract Cannabinoids are compounds isolated from cannabis and are also widely present in both nervous and immune systems of animals.…
Cannabidiol interacts with the FXR/Nrf2 pathway and changes the CB1/CB2 receptors ratio in gentamicin-induced kidney injury in rats
Abstract Objective(s): Gentamicin-induced nephrotoxicity was used as an experimental model of kidney disease. The present study was performed to assess…