A Pan-Cancer Study of Epidermal Growth Factor-Like Domains 6/7/8 as Therapeutic Targets in Cancer
Abstract With highly homologous epidermal growth factor (EGF)-like (EGFL) domains, the members of the EGFL family play crucial roles in…
cancer survival
The variable association between expression and methylation of estrogen receptors and the survival of patients with different tumors
Abstract Background: Estrogen receptor (ER) is essential in reproductive development and is also the primary driver of breast cancers. Deregulation…
A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer
Abstract Background: Initially characterized as axon guidance factors, semaphorins also have been implicated to have critical roles in multiple physiological…
Two miRNA prognostic signatures of head and neck squamous cell carcinoma: A bioinformatic analysis based on the TCGA dataset
Abstract MicroRNAs(miRNAs) are maladjusted in multifarious malignant tumor and can be considered as both carcinogens and tumor‐inhibiting factor. In the…
Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes
Abstract Background: Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to…
Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers
Abstract It has been proposed that the circadian rhythm generally plays important roles in tumor suppression, but there is also…
SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies
Abstract Deletions of chromosome 1p36 are common in cancers; however, despite extensive studies, there has been limited success for discovering…
Treatment of Gastric Adenocarcinoma May Differ Among Hospital Types in the United States, a Report from the National Cancer Data Base
Abstract The concept that complex surgical procedures should be performed at high-volume centers to improve surgical morbidity and mortality is…