The variable association between expression and methylation of estrogen receptors and the survival of patients with different tumors

Abstract Background: Estrogen receptor (ER) is essential in reproductive development and is also the primary driver of breast cancers. Deregulation of ER may also be involved in tumorigenesis of other organs. To understand the role of ER in different tumor types, pan‐cancer analysis of estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) in various tumors and association with patients’ survival were conducted using The Cancer Genome Atlas (TCGA) data. Results: Gene methylation level was evaluated by the mean methylation