Cannabidiol Enhances SIRT1 and Autophagy for the Maintenance of Human Mesenchymal Stem Cells
Abstract Background/Aim: Mesenchymal stem cells (MSCs) are used to treat various degenerative diseases. However, their therapeutic potential is limited by…
cancer stemness
IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization
Abstract Thyroid cancer is the most common endocrine malignancy globally. While papillary thyroid carcinoma (PTC) typically exhibits favorable prognosis, a…
Integrative analysis identifies TEAD4 as a universal prognostic biomarker in human cancers
Abstract Introduction: TEA domain transcription factor 4 (TEAD4), a key effector of the Hippo signaling pathway, has been increasingly associated…
Functional characteristics of fresh antitumor immune interferer GDF-15 in multiple cancers
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-16737-4. Article type: Research Article Keywords: GDF-15, Stemness, Diagnosis,…
Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment
Abstract Purpose: The objective of this study was to develop and evaluate a novel classifier and prognostic model based on…
Multi-omics analysis reveals cancer stemness function and establishes a predictive model for thyroid cancer prognosis and immunotherapy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-02813-8. Article type: Research Article Keywords: Cancer stemness, Immunotherapy,…
Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer
Abstract Background: UCK2 (Uridine-Cytidine Kinase 2) is a promising prognostic marker for malignant tumors, but its association with immune infiltration…
Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers
Abstract Background: SET domain‐containing protein 4 (SETD4) is a histone methyltransferase that has been shown to modulate cell proliferation, differentiation,…
Targeting TSPEAR-AS2 suppresses tumor growth and interferon signaling in esophageal cancer
Abstract Dysregulation of long non-coding RNAs (lncRNAs) and interferon signaling contributes to tumorigenesis and progression; however, their crosstalk in tumor…
The Epigenetic Modifiers HDAC2 and HDAC7 Inversely Associate with Cancer Stemness and Immunity in Solid Tumors
Abstract Dysregulation of histone deacetylases (HDACs) is closely associated with cancer development and progression. Here, we comprehensively analyzed the association…