Methylation-Driven Gene PLAU as a Potential Prognostic Marker for Differential Thyroid Carcinoma
Abstract Purpose: Aberrant DNA methylation plays a crucial role in the tumorigenesis of differentiated thyroid cancer (DTC); nevertheless, the factors…
Cancer prognosis
An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13
Abstract Background: C-X-C Motif Chemokine Ligand 13 (CXCL13) plays a crucial part in the pathogenesis of numerous lymphoproliferative disorders, inflammatory…
Bioinformatics Analysis of Prognostic Value of SPC24 in ccRCC and Pan-Cancer
Abstract Purpose: Clear cell renal cell carcinoma (ccRCC) is one of the most common diseases in the world, with high…
Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers
Abstract Secreted phosphoprotein 1 (SPP1) is involved in immune regulation, cell survival, and tumor progression. Studies have demonstrated that SPP1…
Prognostic Implication and Oncogenic Role of PNPO in Pan-Cancer
Abstract Objective: Pyridoxine 5′-phosphate oxidase (PNPO) is a key enzyme in the metabolism of vitamin B6 and affects the tumorigenesis…
Genetic Alteration, Prognostic and Immunological Role of Acyl-CoA Synthetase Long-Chain Family Member 4 in a Pan-Cancer Analysis
Abstract Acyl-CoA Synthetase long-chain family member 4 (ACSL4) is a member of acyl-CoA synthetase protein long-chain family, which is associated…
Role of Hub Genes in the Occurrence and Development of Testicular Cancer Based on Bioinformatics
Abstract Background: Testicular cancer severely affects male health, so finding effective diagnosis and prognostic indicators and exploring its pathogenesis are…
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker
Abstract Background: Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme encoded by coactivator associated arginine methyltransferase 1 (CARM1)…
Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis
Abstract Simple Summary: Somatic mutations are one of the most important causal factors of cancers. In this study, we show…
Screening and Comprehensive Analysis of Cancer-Associated tRNA-Derived Fragments
Abstract tRNA-derived fragments (tRFs) constitute a novel class of small non-coding RNA cleaved from tRNAs. In recent years, researches have…