Bystin is a Prognosis and Immune Biomarker: From Pan-Cancer Analysis to Validation in Breast Cancer
Abstract Introduction: The Bystin gene (BYSL) contributes to cancer development and is a probable therapeutic target in cancer therapy. However,…
Cancer prognosis
Identification and validation of a novel lymph node metastasis-related model for papillary thyroid carcinoma to predict the prognosis
Abstract Background: Papillary thyroid carcinoma (PTC) is a common malignancy with a good prognosis, but lymph node metastasis (LNM) is…
Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity
Abstract Background: With the sharp increase in the incidence of papillary thyroid carcinoma (PTC), the disease-specific survival rate has not…
An integrative pan-cancer analysis of USP37 and functional validation in pancreatic cancer
Abstract Background: USP37, a versatile deubiquitinase, plays a pivotal role in numerous cellular functions. Although its involvement in cancer development…
Functional characteristics of fresh antitumor immune interferer GDF-15 in multiple cancers
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-16737-4. Article type: Research Article Keywords: GDF-15, Stemness, Diagnosis,…
ZBED4: A Prognostic Biomarker and Therapeutic Target in Hepatocellular Carcinoma
Abstract Background: Hepatocellular carcinoma (HCC) is a prevalent lethal cancer that remains challenging to treat. Therefore, investigation of novel targets…
Comprehensive pan-cancer analysis reveals ubiquitin-conjugating enzyme 2T as a potential biomarker for prognosis and cancer immunity
Abstract Ubiquitin-conjugating enzyme 2T (UBE2T) constitutes a critical component of the ubiquitin-proteasome system and is involved in tumorigenesis. The UBE2T…
CD99 is a potential diagnostic and immunological biomarker in pan-cancer
Abstract Background: As a cell adhesion factor, cluster of differentiation 99 (CD99) mainly plays a role in regulating cell differentiation.…
Pan-Cancer Analysis of GPR141: Unveiling its prognostic significance, immune microenvironment interactions, and therapeutic potential
Abstract Background: GPCRs play an important role in the development of cancer. However, as a member of the G protein-coupled…
The value of nucleoporin 188 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to gastric cancer verification
Abstract Background: Nucleoporin 188 (NUP188) is a vital component of the nuclear pore complex that regulates cancer progression, but its…