Comprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer
Abstract Objective: It has been demonstrated that IDO1, a target of immune checkpoint inhibition, functions as an oncogene in the…
Cancer prognosis
The prognostic values and immune characteristics of polo-like kinases (PLKs) family: A pan-cancer multi-omics analysis
Abstract Background: In the realm of tumor-targeted therapeutics, Polo-like kinases (PLKs) are a significant group of protein kinases that were…
Elevated PDE4C level serves as a candidate diagnostic biomarker and correlates with poor survival in thyroid carcinoma
Abstract Thyroid carcinoma (THCA) is the most common endocrine cancer. Phosphodiesterase (PDE) 4 enzyme family, as specific regulator of cyclic…
Apolipoprotein E is a Potential Biomarker for Predicting Cancer Prognosis and is Correlated with Immune Infiltration
Abstract Background: Apolipoprotein E (APOE) is a polymorphic protein that plays a role in lipoprotein transformation and metabolism. It is…
CDK12 is a potential biomarker for diagnosis, prognosis and immunomodulation in pan-cancer
Abstract Cell cycle-dependent protein kinase 12 (CDK12) plays a key role in a variety of carcinogenesis processes and represents a…
Pan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-024-12039-6. Article type: Research Article Keywords: Pan-cancer analysis, Prognosis,…
Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
Abstract Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating…
Multi-omics analysis of TLCD1 as a promising biomarker in pan-cancer
Abstract Background: The TLC Domain Containing 1 (TLCD1) protein, a key regulator of phosphatidylethanolamine (PE) composition, is distributed across several…
Clinical significance of small nuclear ribonucleoprotein U1 subunit 70 in patients with hepatocellular carcinoma
Abstract Background & Aims: Small nuclear ribonucleoprotein U1 subunit 70 (SNRNP70) as one of the components of the U1 small…
Pancancer analysis of the prognostic and immunological role of FANCD2: a potential target for carcinogenesis and survival
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12920-024-01836-4. Article type: Research Article Keywords: Pan-cancer analysis, Prognosis,…