Integrated pan-cancer analysis of CSMD2 as a potential prognostic, diagnostic, and immune biomarker
Abstract The protein encoded by CUB and Sushi Multiple Domains 2 (CSMD2) is likely involved in regulating the complement cascade…
Cancer microenvironment
Acid–base Homeostasis and Implications to the Phenotypic Behaviors of Cancer
Abstract Acid–base homeostasis is a fundamental property of living cells, and its persistent disruption in human cells can lead to…
Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors
Abstract MAPK signaling inhibitor (MAPKi) therapies show limited efficacy for advanced thyroid cancers despite constitutive activation of the signaling correlates…
RFC2: a prognosis biomarker correlated with the immune signature in diffuse lower-grade gliomas
Abstract Diffuse lower-grade gliomas (LGG) represent the highly heterogeneous and infiltrative neoplasms in the central nervous system (CNS). Replication factor…
A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
Abstract T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression.…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…