RKIP Pleiotropic Activities in Cancer and Inflammatory Diseases: Role in Immunity
Abstract Simple Summary: The human body consists of tissues and organs formed by cells. In each cell there is a…
cancer immunotherapy
Characterization of the Immune Cell Infiltration Landscape of Thyroid Cancer for Improved Immunotherapy
Abstract Within the endocrine system, thyroid cancer (THCA) is the most typical malignant tumor. Tumor-infiltrating immune cells play vital roles…
Analysis of Prognostic Alternative Splicing Reveals the Landscape of Immune Microenvironment in Thyroid Cancer
Abstract Background: The incidence of thyroid cancer (THCA) continues to increase in recent decades. Accumulating evidence showed that the unbalanced…
The spliceosome pathway activity correlates with reduced anti-tumor immunity and immunotherapy response, and unfavorable clinical outcomes in pan-cancer
Keywords: Spliceosome pathway, Pan-cancer, Anti-tumor immunity, Cancer immunotherapy, Drug response, Genomic instability Authors: Zuobing Chen, Canping Chen, Lin Li, Tianfang…
Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy
Abstract Colorectal cancer is a major public health problem. Unfortunately, currently, no effective curative option exists for this type of…
The molecular feature of macrophages in tumor immune microenvironment of glioma patients
Keywords: CDF, cumulative distribution function, CGGA, Chinese Glioma Genome Atlas, CNA, copy number alternations, CNV, copy number variation, CSF-1, colony-stimulating…
Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy
Abstract The interaction of immune checkpoint molecules in the tumor microenvironment reduces the anti-tumor immune response by suppressing the recognition…
Tau immunotherapy is associated with glial responses in FTLD-tau
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-021-02318-y. Article type: Research Article Keywords: Tau, Immunotherapy, Gosuranemab,…
CD73, Tumor Plasticity and Immune Evasion in Solid Cancers
Abstract Simple Summary: Tumors are ecosystems composed of cancer cells and non-tumor stroma together in a hypoxic environment often described…
Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity
Abstract Simple Summary: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has recently attracted increasing attention due to the emerging novel functions…