Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer
Abstract Ferroptosis is a type of cell death related to cancer; however, the characteristics of ferroptosis in cancers are still…
Cancer genomics
Multi-omic signatures identify pan-cancer classes of tumors beyond tissue of origin
Abstract Despite recent advances in treatment, cancer continues to be one of the most lethal human maladies. One of the…
Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Abstract Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter…
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers
Abstract Recent cancer studies have found that the netrin family of proteins plays vital roles in the development of some…
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Abstract Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…
CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications
Abstract Somatic copy number alterations (CNAs) are a hallmark of cancer, but their role in tumorigenesis and clinical relevance remain…
A pan-cancer somatic mutation embedding using autoencoders
Abstract Background: Next generation sequencing instruments are providing new opportunities for comprehensive analyses of cancer genomes. The increasing availability of…
Identification of 12 cancer types through genome deep learning
Abstract Cancer is a major cause of death worldwide, and an early diagnosis is required for a favorable prognosis. Histological…
CPEM: Accurate cancer type classification based on somatic alterations using an ensemble of a random forest and a deep neural network
Abstract With recent advances in DNA sequencing technologies, fast acquisition of large-scale genomic data has become commonplace. For cancer studies,…