Nutrients and Bioactive Compounds from Cannabis sativa Seeds: A Review Focused on Omics-Based Investigations
Abstract Hemp (Cannabis sativa L.) is a versatile crop that can be processed to obtain different products with multiple applications.…
Cancer genomics
The promising role of nanopore sequencing in cancer diagnostics and treatment
Abstract Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a…
Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture
Abstract Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations…
Cannabinoid hyperemesis syndrome: genetic susceptibility to toxic exposure
Abstract Cannabinoid hyperemesis syndrome presents as a complex of symptoms and signs encompassing nausea, vomiting, abdominal pain, and hot water…
Finally Freed—Cannabis in South Africa: A Review Contextualised within Global History, Diversity, and Chemical Profiles
Abstract Cannabis sativa L. is a monotypic genus belonging to the family Cannabaceae. It is one of the oldest species…
An elevated rate of whole-genome duplications in cancers from Black patients
Abstract In the United States, Black individuals have higher rates of cancer mortality than any other racial group. Here, we…
Molecular Mechanisms Underlying Potential Pathogen Resistance in Cannabis sativa
Abstract Cannabis (Cannabis sativa L.) is one of the earliest cultivated crops, valued for producing a broad spectrum of compounds…
Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation
Abstract Background: Cannabinoid hyperemesis syndrome (CHS) is a diagnosis of exclusion with intractable nausea, cyclic vomiting, abdominal pain, and hot…
Cannabis labelling is associated with genetic variation in terpene synthase genes
Abstract Analysis of over 100 Cannabis samples quantified for terpene and cannabinoid content and genotyped for over 100,000 single nucleotide…
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm
Abstract Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or…