The promising role of nanopore sequencing in cancer diagnostics and treatment
Abstract Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a…
Cancer genomics
Digital profiling of gene expression from histology images with linearized attention
Abstract Cancer is a heterogeneous disease requiring costly genetic profiling for better understanding and management. Recent advances in deep learning…
Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture
Abstract Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations…
Cannabinoid hyperemesis syndrome: genetic susceptibility to toxic exposure
Abstract Cannabinoid hyperemesis syndrome presents as a complex of symptoms and signs encompassing nausea, vomiting, abdominal pain, and hot water…
Comprehensive pan-cancer analysis of FUTs family as prognostic and immunity markers based on multi-omics data
Abstract Background: The dysregulation of fucosyltransferases (FUTs) contributes to alterations in fucosylated epitope expression, which serve as distinctive features of…
Multi-omics analysis identifies BCAT2 as a potential pan-cancer biomarker for tumor progression and immune microenvironment modulation
Abstract Branched-chain amino acid transaminase 2 (BCAT2) encodes a crucial protein involved in the initial catalysis of branched-chain amino acid…
Finally Freed—Cannabis in South Africa: A Review Contextualised within Global History, Diversity, and Chemical Profiles
Abstract Cannabis sativa L. is a monotypic genus belonging to the family Cannabaceae. It is one of the oldest species…
An elevated rate of whole-genome duplications in cancers from Black patients
Abstract In the United States, Black individuals have higher rates of cancer mortality than any other racial group. Here, we…
Impact of Hashimoto’s thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis
Abstract This study investigates the impact of Hashimoto’s thyroiditis (HT), an autoimmune disorder, on the papillary thyroid cancer (PTC) microenvironment…
Identifying cell lines across pan-cancer to be used in preclinical research as a proxy for patient tumor samples
Abstract In pre-clinical trials of anti-cancer drugs, cell lines are utilized as a model for patient tumor samples to understand…