A pan-cancer analysis of the role of USP5 in human cancers
Abstract Posttranslational modifications (PTM) such as acetylation, deubiquitination, and phosphorylation of proteins, play important roles in various kinds of cancer…
cancer genetics
CEP55: an immune-related predictive and prognostic molecular biomarker for multiple cancers
Abstract Background: Centrosomal protein 55 (CEP55) plays a significant role in specific cancers. However, comprehensive research on CEP55 is lacking…
The prognostic value and immunological role of CD44 in pan-cancer study
Abstract To investigate the correlation between cluster of differentiation-44 (CD44) expression and immunotherapy response and identify its possible predictive value…
Spectrum of BRCA1 interacting helicase 1 aberrations and potential prognostic and therapeutic implication: a pan cancer analysis
Abstract BRCA1 interacting helicase 1 (BRIP1) alteration was crucial in tumors and it was a potential therapeutic target in ovarian…
Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer
Abstract Methyl-CpG-binding protein 2(MeCP2) is an important epigenetic regulatory factor that promotes many tumor developments, such as liver cancer, breast…
The impact of rare germline variants on human somatic mutation processes
Abstract Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types…
An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors
Abstract In recent years, several studies have suggested that mitochondrial creatine kinase 1A (CKMT1A) plays a key role in various…
Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival
Abstract Originally identified on the tongue for their chemosensory role, the receptors for sweet, umami, and bitter taste are expressed…
Pan‐cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis
Abstract Background: Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open…
Genetic fusions favor tumorigenesis through degron loss in oncogenes
Abstract Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in…