Pan-cancer genomic analysis links 3’UTR DNA methylation with increased gene expression in T cells
Abstract Background: Investigations into the function of non-promoter DNA methylation have yielded new insights into the epigenetic regulation of gene…
Cancer epigenetics
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Abstract Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this…
A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers
Abstract Intratumor genetic heterogeneity (ITH) is the main obstacle to effective cancer treatment and a major mechanism of drug resistance.…
The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data
Abstract The KRAB‐ZNF (Krüppel‐associated box domain zinc finger) gene family is composed of a large number of highly homologous genes,…
HOPX homeobox methylation in differentiated thyroid cancer and its clinical relevance
Abstract Background: The inactivation of the tumor-suppressor homeodomain-only protein X (HOPX) usually involves promoter methylation in several cancer types. This…
The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors
Abstract The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during…
Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4
Abstract Background: Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in…
Integrative epigenetic and genetic pan-cancer somatic alteration portraits
Abstract Genetic and epigenetic alterations are required for carcinogenesis and the mutation burden across tumor types has been investigated. Here,…
Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation
Abstract Epigenetic studies have led to a more profound understanding of the mechanisms involved in chronic conditions. In the case…
Pan-cancer analysis of frequent DNA co-methylation patterns reveals consistent epigenetic landscape changes in multiple cancers
Abstract Background: DNA methylation is the major form of epigenetic modifications through which the cell regulates the gene expression and…