Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women
Abstract Background: The use of cannabis has been clinically associated with decreased motivation to engage in normally rewarding activities. However,…
brain-reward system
New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence
Abstract Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity…
Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?
Abstract Obesity is a complex disorder, and the number of people affected is growing every day. In recent years, research…
Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner
Abstract Background: Cannabis exposure during adolescence is associated with emotional and motivational alterations that may entail an enhanced risk of…
The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area
Abstract The therapeutic utility of opioids is diminished by their ability to induce rewarding behaviors that may lead to opioid…
FMRI activation to cannabis odor cues is altered in individuals at risk for a cannabis use disorder
Abstract Introduction: The smell of cannabis is a cue with universal relevance to cannabis users. However, most cue reactivity imaging…
The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers
Abstract Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing…
The Bivalent Rewarding and Aversive properties of Δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions
Abstract The primary psychoactive compound in cannabis, Δ9-tetrahydrocannabinol (THC), is capable of producing bivalent rewarding and aversive affective states through…
Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion
Abstract Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here,…
Individual and combined effects of cannabis and tobacco on drug reward processing in non-dependent users
Abstract Rationale: Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing…