Individual and combined effects of cannabis and tobacco on drug reward processing in non-dependent users
Abstract Rationale: Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing…
brain-reward system
Acute and chronic effects of cannabinoids on effort-related decision-making and reward learning: an evaluation of the cannabis ‘amotivational’ hypotheses
Abstract Rationale: Anecdotally, both acute and chronic cannabis use have been associated with apathy, amotivation, and other reward processing deficits.…
fMRI study of neural sensitization to hedonic stimuli in long‐term, daily cannabis users
Abstract Although there is emergent evidence illustrating neural sensitivity to cannabis cues in cannabis users, the specificity of this effect…
Variable activation in striatal subregions across components of a social influence task in young adult cannabis users
Abstract Introduction: Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but…
Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26
Abstract The therapeutic properties of cannabinoids have been well demonstrated but are overshadowed by such adverse effects as cognitive and…
The CB1 Neutral Antagonist Tetrahydrocannabivarin Reduces Default Mode Network and Increases Executive Control Network Resting State Functional Connectivity in Healthy Volunteers
Abstract Background: The cannabinoid cannabinoid type 1 (CB1) neutral antagonist tetrahydrocannabivarin (THCv) has been suggested as a possible treatment for…
Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers
Abstract Background: Disturbances in the regulation of reward and aversion in the brain may underlie disorders such as obesity and…
Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell
Abstract 2-Arachidonoylglycerol (2-AG) is the most potent endogenous ligand of brain cannabinoid CB1 receptors and is synthesized on demand from…
Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future
Abstract Over the last decades, the endocannabinoid system has been implicated in a large variety of functions, including a crucial…
THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction
Abstract Recent evidence has implicated the endocannabinoid (eCB) system in nicotine addiction. The eCB system also has an important role…