A pan-cancer analysis of the oncogenic role of procollagen C-endopeptidase enhancer (PCOLCE) in human
Abstract There is no evidence showing that the expression of procollagen C-endopeptidase enhancer (PCOLCE) is associated with human tumors, and…
BRAF mutation
Pan‐Cancer analyses of Necroptosis‐Related genes as a potential target to predict immunotherapeutic outcome
Abstract Necroptosis is a unique programmed death mechanism of necrotic cells. However, its role and specific mechanism in cancer remain…
Pan-Cancer Landscape of NEIL3 in Tumor Microenvironment: A Promising Predictor for Chemotherapy and Immunotherapy
Abstract Simple Summary: A reliable efficacy predictor for immunotherapy is warranted due to its unsatisfying responsive rate among cancer patients.…
Pan-cancer analyses reveal multi-omics and clinical characteristics of RIO kinase 2 in cancer
Abstract RIO kinase 2 has emerged as a critical kinase for ribosome maturation, and recently it has also been found…
Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer
Abstract Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the…
A systematic pan-cancer analysis of PXDN as a potential target for clinical diagnosis and treatment
Abstract Peroxidasin (PXDN), also known as vascular peroxidase-1, is a newly discovered heme-containing peroxidase; it is involved in the formation…
Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis
Abstract PBX4 belongs to the pre-B-cell leukemia homeobox (PBX) transcription factors family and acts as a transcriptional cofactor of HOX…
BRAF-activated WT1 contributes to cancer growth and regulates autophagy and apoptosis in papillary thyroid carcinoma
Abstract Background: Papillary thyroid carcinoma (PTC) is one of most prevalent malignant endocrine neoplasms, and it is associated with a…
Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis
Abstract Simple Summary: Somatic mutations are one of the most important causal factors of cancers. In this study, we show…
Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers
Abstract Simple Summary: Thyroid cancer is the most common endocrine malignancy. However, the cytological diagnosis of certain malignant thyroid tumors…