Comprehensive Pan-Cancer Analysis of Heat Shock Protein 110, 90, 70, and 60 Families
Abstract Background: Here we carried out a panoramic analysis of the expression and prognosis of HSP110, HSP90, HSP70, and HSP60…
BRAF mutation
Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome
Abstract Simple Summary: Integrins are cell-extracellular matrix adhesion molecules considered functionally related to the development of cancer metastasis. Starting from…
Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers
Abstract Constitutive MAPK activation silences genes required for iodide uptake and thyroid hormone biosynthesis in thyroid follicular cells. Accordingly, most…
Enolase 1 Correlated With Cancer Progression and Immune-Infiltrating in Multiple Cancer Types: A Pan-Cancer Analysis
Abstract Enolase 1 (ENO1) is an oxidative stress protein expressed in endothelial cells. This study aimed to investigate the correlation…
Pan-cancer analysis of systematic batch effects on somatic sequence variations
Abstract Background: The Cancer Genome Atlas (TCGA) is a comprehensive database that includes multi-layered cancer genome profiles. Large-scale collection of…
Association mining of mutated cancer genes in different clinical stages across 11 cancer types
Abstract Many studies have demonstrated that some genes (e.g. APC, BRAF, KRAS, PTEN, TP53) are frequently mutated in cancer, however,…
A global assessment of cancer genomic alterations in epigenetic mechanisms
Abstract Background: The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation…