Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis
Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies in the world. This study proposes to reveal…
bioinformatics
Pan-cancer analysis of the prognostic and immunological role of matrix metalloproteinase 9
Abstract Matrix metalloproteinase 9 (MMP9), a zinc ion-dependent endopeptidase, is one of the most complex matrix metalloproteinases in the gelatinase…
Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains
Abstract The recent progress in the prediction of protein structures marked a historical milestone. AlphaFold predicted 200 million protein models…
In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity
Abstract Introduction: The oncogenic transformation is driven by genetic and epigenetic alterations influencing cancer cell fate. These alterations also result…
CLDN5 identified as a biomarker for metastasis and immune infiltration in gastric cancer via pan-cancer analysis
Abstract Background: CLDN5 protein is essential for the formation of tight junctions in epithelial cells, and has been associated with…
Pan-cancer analysis identifies LPCATs family as a prognostic biomarker and validation of LPCAT4/WNT/β-catenin/c-JUN/ACSL3 in hepatocellular carcinoma
Abstract Lipid remodeling regulators are now being investigated as potential therapeutic targets for cancer therapy as a result of their…
Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis
Abstract Previous research has demonstrated that ferredoxin 1 (FDX1) contributes to the accumulation of toxic lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and…
CCNF is a potential pancancer biomarker and immunotherapy target
Abstract Background: CCNF catalyzes the transfer of ubiquitin molecules from E2 ubiquitin-conjugating enzymes to target proteins, thereby regulating the G1/S…
Pan-cancer analysis reveals potential of FAM110A as a prognostic and immunological biomarker in human cancer
Abstract Background: Despite great success, immunotherapy still faces many challenges in practical applications. It was previously found that family with…
The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis
Abstract Background: HMGB1 is a highly conserved nuclear protein widely expressed in mammalian cells. This study aimed to comprehensively investigate…