SignatureFinder enables sequence mining to identify cobalamin‐dependent photoreceptor proteins
Abstract Photoreceptors control cellular processes in response to light. Most photoreceptors sense blue or red light, but the recent discovery…
bioinformatics
Impact of pan-cancer analysis of the exportins family on prognosis, the tumor microenvironment and its potential therapeutic efficacy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10238-024-01534-6. Article type: Research Article Keywords: Pan-cancer, Exportin, Prognosis,…
Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells
Abstract Background: Research on the function of HGH1 in breast cancer remains lacking. Methods: TCGAand GEO (GSE45827) datasets investigated discrepancies…
Microbiome diversity and variations in industrial hemp genotypes
Abstract Microbes like bacteria and fungi are crucial for host plant growth and development. However, environmental factors and host genotypes…
Integrative Multi-Omics Analysis Reveals Critical Molecular Networks Linking Intestinal-System Diseases to Colorectal Cancer Progression
Abstract Background/Objectives: Colorectal cancer (CRC) frequently co-occurs with intestinal system diseases (ISDs), yet their molecular interplay remains poorly understood. We…
Identification and validation of a novel prognostic signature and key genes related to development of anaplastic thyroid carcinoma
Abstract Background: Anaplastic thyroid carcinoma (ATC) is a rare but the most aggressive type of thyroid carcinoma. Nevertheless, limited advances…
Protocol to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions with the AVERON Notebook
Abstract While some tumor driver mutations inhibit existing protein-protein interactions (PPIs), others can create neomorph interactions (neoPPIs) not characteristic of…
Comprehensive Pan-Cancer Analysis of the Prognostic Role of KLF Transcription Factor 2 (KLF2) in Human Tumors
Abstract Background: KLF2 is a transcription factor expressed early in mammalian development that plays a role in many processes of…
CXCL8 may serve as a potential biomarker for predicting the prognosis and immune response in cervical cancer
Abstract Objective: To investigate the prognostic significance of CXCL8 in cervical cancer and its effect on immune response based on…
Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer
Abstract Expression of major histocompatibility complex I (MHC-I) on tumor cells is extremely important for the antitumor immune response for…