Therapeutic Activities and Phytochemical Composition of Helianthus annuus L. Extracts
Abstract The sunflower (Helianthus annuus L.) is a plant commonly used in agriculture and the fuel industry, as well as…
behavioral pharmacology
Sex differences in the capacity of minor phytocannabinoids to attenuate nociceptive insults in HIV-1 Tat-expressing mice
Abstract Objecives: Approximately 80 % of people living with HIV (PLWH) develop chronic pain and preclinical studies support the involvement…
In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine
Abstract Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development…
Tetrahydrocannabivarin is Not Tetrahydrocannabinol
Abstract Tetrahydrocannabivarin (THCV) is a phytocannabinoid that is becoming popular across the North American cannabis market. THCV has been reported…
Hypothesized pharmacogenomic and medication influences on tetrahydrocannabinol and cannabidiol metabolism in a cohort of unselected oral cannabis users
Abstract Background: Differences in cannabinoid metabolism and patient responses can arise even with equivalent doses and formulations. Genetic polymorphisms in…
LY-2183240 enhances reward-seeking behavior with inducing neuronal excitation and early apoptosis in mouse
Abstract Cannabinoids interact with cannabinoid receptors, influencing diverse central nervous system (CNS) and peripheral functions, including anxiety, depression, and cognition.…
Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay
Abstract The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived,…
Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol
Abstract Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the…
Cannabidiol for Toothache: Ups, Downs, and Regulatory Considerations
Keywords: pulpitis, pain, pharmacology, drug interactions, off-label use, decision-making Authors: K.N. Theken ⚬, E.V. Hersh ⚬ Affiliations: Department of Oral…
Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold
Abstract TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and…