Metabolic Responses of Melanocytes and Melanoma Cells to UVA Radiation and Phytocannabinoids Exposure
Abstract Ultraviolet A (UVA) radiation disrupts the redox balance of melanocytes and may lead to the development of melanoma, highlighting…
B16F10 melanoma cells
THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells
Abstract In the search for new therapeutic strategies for the treatment of skin cancer, cannabinoids have become the focus of…
Investigating the Synergistic Effect of the Cannabis Extract PHEC-66 and Chemotherapeutic Agents on Human Melanoma Cells
Abstract Melanoma is a malignant neoplasm that originates from melanocytes. It continues to pose a significant challenge in oncology due…
Skin-Whitening Effects of Cannabinol (CBN) Through Melanin Inhibition in B16F10 Melanoma Cells
Abstract Melanogenesis, the key biological process underlying skin hyperpigmentation, is tightly regulated by complex molecular signaling pathways. Consequently, targeting molecular…
Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells
Abstract Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However, the cytotoxic…
Evaluating the Mechanism of Cell Death in Melanoma Induced by the Cannabis Extract PHEC-66
Abstract Research suggests the potential of using cannabinoid-derived compounds to function as anticancer agents against melanoma cells. Our recent study…
AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
Abstract Background: Despite great advances in our understanding of the impact of cannabinoids on human organism, many of their properties…
In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines
Abstract Melanoma, an aggressive form of skin cancer, can be fatal if not diagnosed and treated early. Melanoma is widely…
Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering
Abstract Background: Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to…
Cannabinoids Reduce Melanoma Cell Viability and Do Not Interfere with Commonly Used Targeted Therapy in Metastatic Melanoma In Vivo and In Vitro
Abstract Simple Summary: Cannabinoids are mainly used for recreational purposes but find their way into oncology due to ongoing legalization…