Decreased expression of SCARA5 predicts a poor prognosis in melanoma using bioinformatics analysis
Abstract Background: It has been established that the scavenger receptor class A member 5 (SCARA5) functions as a tumor suppressor…
B16F10 melanoma cells
Analysis of gene expression levels and their impact on survival in 31 cancer-types patients identifies novel prognostic markers and suggests unexplored immunotherapy treatment options in a wide range of malignancies
Abstract Background: Immunotherapy has dramatically improved cancer treatment by inhibiting or activating specific cell receptors, thus unleashing the host anti-tumor…
The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer
Abstract The endocannabinoid system is widespread through the body and carries out a wide variety of functions. However, its involvement…
Optimisation of the Green Process of Industrial Hemp—Preparation and Its Extract Characterisation
Abstract Natural medicines and products are becoming increasingly important in the pharmaceutical and food industries. The most important step in…
Cannabidiol Interacts Antagonistically with Cisplatin and Additively with Mitoxantrone in Various Melanoma Cell Lines—An Isobolographic Analysis
Abstract The medical application of cannabidiol (CBD) has been gathering increasing attention in recent years. This non-psychotropic cannabis-derived compound possesses…
Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
Abstract The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events,…
Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma
Abstract The underlying molecular mechanisms of the aberrant expression of components of the HLA class I antigen processing and presentation…