Epilepsy, neuroinflammation and cannabidiol What do we know thus far?
Abstract Epilepsy is a common neurological disorder associated with recurring seizures that in about one-third of individuals are resistant to…
audiogenic seizures
Computational drug repositioning approach to predict multi-target therapeutics for epilepsy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-27625-2. Article type: Research Article Keywords: AED, Drug repurposing/Repositioning,…
Cannabidiol combined with GABAergic drugs but not with sodium channel blockers prevents the development of drug-resistance seizures in a preclinical model
Abstract Drug resistance affects 30% of patients with epilepsy. Cannabidiol (CBD) decreases the expression of drug-resistant seizures in specific syndromes.…
Practical approach to the safe use of cannabidiol in patients with refractory epilepsy: a mini review
Abstract Drug-resistant epilepsy (DRE), characterized by seizures that are unresponsive to the use of two or more conventional anti-seizure medication…
19 patients report seizure freedom with medical cannabis oil treatment for drug-resistant epilepsy: a case series
Abstract Purpose: Seizure freedom (SF) is the primary goal of epilepsy treatment. More treatments that produce SF in drug-resistant epilepsy…
Clinical and Public Health Challenge of Handling Synthetic Cathinone and Cannabinoid Abuse in Pediatric Care: A Narrative Review
Abstract Background: Synthetic cathinones and cannabinoids have emerged as significant public health concerns, particularly in pediatric populations. Marketed under deceptive…
Cost-Utility Analysis of Add-on Cannabidiol vs Usual Care Alone for the Treatment of Seizures in Patients With Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the Netherlands
Abstract Background: Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) are severe, treatment-refractory, epileptic encephalopathies that often develop in infancy or…
The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study
Abstract Background: Approximately 30% of dogs with idiopathic epilepsy (IE) are drug‐resistant. Recent studies have suggested cannabidiol (CBD) may be…
Audiogenic epileptic DBA/2 mice strain as a model of genetic reflex seizures and SUDEP
Abstract Epilepsy is a chronic neurological disease characterized by abnormal brain activity, which results in repeated spontaneous seizures. Sudden unexpected…
Disposition of a single oral dose of a cannabidiol medication in healthy cats
Abstract The historical use of the marijuana plant for medicinal purposes is long. One of the historical uses has been…