CNR1 and CNR2 Cannabinoid Receptor Mutations in Cancer Cells
Abstract Cannabinoids, including the psychoactive D9-tetrahydrocannabinol (THC) and the non-psychoactive cannabidiol (CBD), interact with receptors within the endocannabinoid system. The…
atypical cannabinoid receptors
Integrative network analysis reveals organizational principles of the endocannabinoid system
Abstract Background: The endocannabinoid system (ECS) is a complex signaling network that regulates diverse physiological processes, including pain, mood, metabolism,…
The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic Potential
Abstract The endocannabinoid system (ECS) is a fundamental regulator of brain and body homeostasis, integrating neural, immune, and stress-related signaling…
CBD Promotes Structural and Functional Epithelial Restoration and Alleviates Inflammation in a Mouse Model of Interstitial Cystitis
Abstract Background: Interstitial cystitis (IC) is a debilitating lower urinary tract condition characterised by chronic inflammation of the bladder. As…
Cannabidiol Regulates CD47 Expression and Apoptosis in Jurkat Leukemic Cells Dependent upon VDAC-1 Oligomerization
Abstract Background: Cannabidiol (CBD) is a major non-psychoactive phytocannabinoid that exerts multiple biological effects in the body. It has been…
The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation
Abstract The endocannabinoid system (ECS) is a primary regulatory system in human physiology that serves to help maintain homeostasis throughout…
Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method
Abstract New psychoactive substances (NPS) targeting human cannabinoid receptor 1 pose a significant threat to society as recreational abusive drugs…
Cannabinoids in immune system-related diseases: From bench to clinic
Abstract As a psychoactive drug, marijuana is used for recreational purposes. Given its addictive nature and the serious damage it…
Metabolism of Cannabidiol in Respiratory-Associated Cells and HepG2-Derived Cells and Molecular Docking of Cannabidiol and Its Metabolites with CYP Enzymes and Cannabinoid Receptors
Abstract Cannabidiol (CBD) has been reported in medical applications for various indications. The enzymatic metabolism of CBD is not fully…
Cannabinoid Receptor Modulation in Focal Ischemic Stroke: A Systematic Review and Meta-Analysis of Infarct Volume and Behavioral Deficits in Animal Models
Abstract Objective: This systematic review and meta-analysis aimed to evaluate the impact of cannabinoid (CB) receptor modulation on infarct volume…