Sperm capacitation and transcripts levels are altered by in vitro THC exposure
Abstract Background: Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact…
Apoptosis
The oncogenic and immunological roles of histidine triad nucleotide-binding protein 1 in human cancers and their experimental validation in the MCF-7 cell line
Abstract Background: Histidine triad nucleotide binding protein 1 (HINT1) is a haplo-insufficient tumor suppressor gene that plays a significant role…
Cannabinoid Mixture Affects the Fate and Functions of B Cells through the Modulation of the Caspase and MAP Kinase Pathways
Abstract Cannabis use is continuously increasing in Canada, raising concerns about its potential impact on immunity. The current study assessed…
Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
Abstract Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used in the treatment of mental…
The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy
Abstract Simple Summary: The survival rate of head and neck cancer has only improved slightly over the last quarter century,…
Natural essential oils as a new therapeutic tool in colorectal cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12935-022-02806-5. Article type: Review Article Keywords: Colorectal cancer, Natural…
Cannabidiol and Its Combinations with Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis and Inhibit Activation of NF-κB Signaling in Vulvar Squamous Cell Carcinoma
Abstract Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with a relatively good prognosis. However, the prognosis remains poor…
Resident Astrocytes can Limit Injury to Developing Hippocampal Neurons upon THC Exposure
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s11064-022-03836-1. Article type: Research Article Keywords: Cell proliferation, Cannabis,…
Phytocannabinoid Compositions from Cannabis Act Synergistically with PARP1 Inhibitor against Ovarian Cancer Cells In Vitro and Affect the Wnt Signaling Pathway
Abstract Ovarian cancer (OC) is the single most lethal gynecologic malignancy. Cannabis sativa is used to treat various medical conditions,…
Cytotoxic Effects of Cannabidiol on Neonatal Rat Cortical Neurons and Astrocytes: Potential Danger to Brain Development
Abstract The influence of cannabidiol (CBD) on brain development is inadequately understood. Since CBD is considered a non-intoxicating drug, it…