GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis
Abstract GPX4 has attracted much attention as a key molecule of cell ferroptosis, but its role in cell apoptosis is…
Apoptosis
Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells
Abstract Cannabinoids have been shown to induce anti‐tumor activity in a variety of carcinoma cells such as breast, prostate, and…
In Vitro Evidence of Selective Pro-Apoptotic Action of the Pure Cannabidiol and Cannabidiol-Rich Extract
Abstract Plant cannabinoids, secondary metabolites of species belonging to the Cannabis genus, can mimic the endocannabinoids’ action and exert biological…
In vitro evaluation of cell viability and expression profile of growth factors in mouse Sertoli cells exposed to Delta-9-tetrahydrocannabinol: a mechanistic insight into the cannabinoid-induced testicular toxicity
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40360-023-00704-8. Article type: Research Article Keywords: Apoptosis, Endocannabinoid system,…
Development, Characterization and Pharmacological Evaluation of Cannabidiol-Loaded Long Circulating Niosomes
Abstract Cannabidiol (CBD) is a promising drug candidate with pleiotropic pharmacological activity, whose low aqueous solubility and unfavorable pharmacokinetics have…
Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma
Abstract Simple Summary: This study provides evidence that cabozantinib and CBD combination treatment leads to increased apoptosis in HCC cells.…
Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal Carcinogenesis
Abstract Cannabis sativa is a multipurpose plant that has been used in medicine for centuries. Recently, considerable research has focused…
The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model
Abstract Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol (THC); however, up to 120 types of…
Role of Terpenophenolics in Modulating Inflammation and Apoptosis in Cardiovascular Diseases: A Review
Abstract One in every three deaths worldwide is caused by cardiovascular diseases (CVDs), estimating a total of 17.9 million deaths…
The prognostic and immune significance of C15orf48 in pan-cancer and its relationship with proliferation and apoptosis of thyroid carcinoma
Abstract Background: C15orf48 was recently identified as an inflammatory response-related gene; however there is limited information on its function in…