Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines
Abstract Cancer is a non‐communicable disease and is one of the leading causes of mortality worldwide. While plant‐derived compounds have…
Apoptosis
The potential role of cannabidiol (CBD) in lung cancer therapy: a systematic review of preclinical and clinical evidence
Abstract Background: Lung cancer is one of the most prevalent and lethal cancers worldwide, with limited therapeutic options in advanced…
Design, Synthesis, and Molecular Docking of Triazole‐Coumarin Hybrids as Potent Breast Cancer Inhibitors Targeting Cell Cycle and Apoptosis
Abstract Breast cancer continues to pose a significant global health burden, highlighting the urgent need for novel chemotherapeutic agents with…
Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)
Abstract Unregulated epigenetic modifications, including histone acetylation/deacetylation mediated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), contribute to cancer progression.…
Integrating Multi‐Omics Data Using Machine Learning to Explore New Therapeutic Targets for Acute Kidney Injury
Abstract Renal ischemia–reperfusion (I/R) injury is an unavoidable complication associated with renal transplantation, and currently, there are no targeted therapeutic…
Transcriptional enhanced associate domain factor 1 regulates cortactin-binding protein 2 N-terminal-like to control cell apoptosis in thyroid cancer
Abstract Objective: Understanding the molecular mechanisms underlying papillary thyroid carcinoma (PTC) is crucial for identifying drug targets. This research aims…
Loganic acid ameliorates diabetic cardiomyopathy via suppressing TLR4/p38 MAPK signaling-mediated oxidative stress and inflammation
Abstract Diabetic cardiomyopathy (DCM), a life-threatening cardiovascular complication of diabetes, manifested as progressive cardiac dysfunction mediated through oxidative stress, inflammation,…
ANTP-SmacN7 enhances radiosensitivity in TPC-1 cells through XIAP-mediated activation of apoptotic protein
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-11131-6. Article type: Research Article Keywords: PTC, ANTP-SmacN7, XIAP,…
Cannabidiol (CBD) as a potential therapeutic agent for liver cancer: a comprehensive review of current evidence
Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality with limited treatment options. Cannabidiol (CBD), a non-psychoactive compound…
Elucidating the transcriptomic response of adult-derived mHypoA-2/12 mouse hypothalamic neuron cell line to cannabidiol (CBD) exposure
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s13353-025-00970-8. Article type: Research Article Keywords: CBD, Hypothalamic neurons,…