Pro-Apoptotic Effects of Anandamide in Human Gastric Cancer Cells Are Mediated by AKT and ERK Signaling Pathways
Abstract Gastric cancer is one of the most common forms of cancer worldwide. A growing number of studies have addressed…
Apoptosis
Cannabidiol protects lung against inflammation and apoptosis in a rat model of blunt chest trauma via Bax/Bcl-2/Cas-9 signaling pathway
Abstract Purpose: This study aimed to investigate the hypothesis that cannabidiol (CBD), with known anti-inflammatory and anti-apoptotic effects, would reduce…
Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics
Abstract The present study was aimed at revealing the metabolic changes that occurred in the cellular lipid pattern of acute…
Cannabigerol Treatment Shows Antiproliferative Activity and Causes Apoptosis of Human Colorectal Cancer Cells
Abstract Objectives: To determine growth inhibitory and anti-cancer effects of Cannabigerol (CBG) in human colorectal cancer cells. Methods: Anti-proliferative effect…
The molecular anti-metastatic potential of CBD and THC from Lebanese Cannabis via apoptosis induction and alterations in autophagy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-76340-x. Article type: Research Article Keywords: Breast cancer, Cannabinoids,…
Exploring the therapeutic potential of cannabinoids in cancer by modulating signaling pathways and addressing clinical challenges
Abstract For centuries, cannabinoids have been utilized for their medicinal properties, particularly in Asian and South-Asian countries. Cannabis plants, known…
Receptors and Signaling Pathways Controlling Beta-Cell Function and Survival as Targets for Anti-Diabetic Therapeutic Strategies
Abstract Preserving the function and survival of pancreatic beta-cells, in order to achieve long-term glycemic control and prevent complications, is…
Tandem Mass Tag-10plex (TMT-10plex) phosphoproteomics dataset for comprehensive analysis of active compounds with tyrosine kinase inhibition activity
Abstract Bioactive compounds derived from natural products demonstrate a wide range of beneficial properties in cancer treatment. One popular approach…
Anti-Cancer and Anti-Proliferative Potential of Cannabidiol: A Cellular and Molecular Perspective
Abstract Cannabinoids, the bioactive compounds found in Cannabis sativa, have been used for medicinal purposes for centuries, with early discoveries…
A comprehensive review on phytochemicals in the treatment and prevention of pancreatic cancer: Focusing on their mechanism of action
Abstract Background and Aims: Pancreatic cancer develops in the normal tissues of the pancreas from malignant cells. The chance of…